Main publications

  • Almeida L, Poulain A, Pourtier A, Villa C. Mathematical modelling of the contribution of senescent fibroblasts to basement membrane digestion during carcinoma invasion. Math. Model. Nat. Phenom. 21 (2026) 11. doi.org/10.1051/mmnp/2026002
  • Truchi M, Gautier-Isola M, Savary G, Scribe C, Lingampally A, Cadis H, Baeri A , Magnone V, Girard-Riboulleau C, Arguel M, de Schutter C, Fassy J, Boukrout N, Larrue R, Martin N, Rezzonico R, Pluquet O, Perrais M, Hofman V, Marquette C, Hofman P, Günther A, Ricard N, Barbry P, Leroy S, Lebrigand K, Bellusci S, Cauffiez C, Vassaux G, Pottier N, Mari B. Aging affects reprogramming of pulmonary capillary endothelial cells after lung injury in male mice. Nat Commun. 2025. doi: 10.1038/s41467-025-62431-4.
  • Giroud J, Combémorel E, Pourtier A, Abbadie C, Pluquet O. Unraveling the functional and molecular interplay between cellular senescence and the unfolded protein response. Am J Physiol Cell Physiol. 2025 Jun 1;328(6):C1764-C1782. doi: 10.1152/ajpcell.00091.2025.
  • Giroud J, Delvaux P, Carlier L, De Schutter C, Martin N, Rouget R, Bolouki A, De Glas V, Bouriez I, Bourdoux F, Burteau S, Théry J, Decanter G, Penel N, de Launoit Y, Ledoux B, Abbadie C, Poumay Y, Pluquet O, Debacq-Chainiaux F. Targeting ATF6α Attenuates UVB-Induced Senescence and Improves Skin Homeostasis by Regulating IL8 Expression. Aging Cell. 2025 Jun;24(6):e70024. doi: 10.1111/acel.70024.
  • Pioger A, Loison I, Metatla I, Spruyt N, Abbadie C, Dehennaut V. Comparative analysis of senescence induction by different chemotherapeutic agents in HCT116 colon cancer cells. Biochem Biophys Res Commun. 2025 Mar 8;752:151482. doi: 10.1016/j.bbrc.2025.151482.
  • ​​​​​​​Delage C, Andreani M, Boukrout N, Sabaouni N, Perrais M, Lefebvre B, Cauffiez C, Pottier N, Larrue R. Whole-genome sequencing revealed a novel structural variant in COL4A4 causing autosomal dominant Alport syndrome: A case report. Heliyon. 2024 Nov 28;10(24):e40802.  doi: 10.1016/j.heliyon.2024.e40802.
  • Srour E, Martin N, Drullion C, De Schutter C, Giroud J, Pioger A, Deslé J, Saas L, Nassour J, Théry J, Decanter G, Penel N, Vercamer C, Salazar-Cardozo C, Abbadie C, Pluquet O. Prostaglandin E2 regulates senescence and post-senescence neoplastic escape in primary human keratinocytes. Aging (Albany NY). 2024 Nov 18;16(21):13201-13224. doi: 10.18632/aging.206149.
  • Hamroun A, Boukrout N, Cauffiez C, Fellah S, Van der Hauwaert C, Pottier N, Mentaverri R, Zaworski J, Gnemmi V, Gibier J, Letavernier E, Louvet A, Provôt F, Lenain R, Maanaoui M, Glowacki F, Lionet A. Severe hypophosphatemia induced by excessive production of FGF23 in acute hepatitis: from bedside to bench. Clin Kidney J. 2024 Oct 9;17(11):sfae307.  doi: 10.1093/ckj/sfae307
  • Loison I, Pioger A, Paget S, Metatla I; OrgaRES Consortium; Vincent A, Abbadie C, Dehennaut V. O-GlcNAcylation inhibition redirects the response of colon cancer cells to chemotherapy from senescence to apoptosis. Cell Death Dis. 2024 Oct 19;15(10):762. doi: 10.1038/s41419-024-07131-5.
  • Rodzinski É, Martin N, Rouget R, Pioger A, Dehennaut V, Molendi-Coste O, Dombrowicz D, Goy E, de Launoit Y, Abbadie C. [Sorting of senescent cells by flow cytometry: Specificities and pitfalls to avoid]. Med Sci (Paris). 2024 Mar;40(3):275-282. doi: 10.1051/medsci/2024011.
  • Hamroun A, Decaestecker A, Larrue R, Fellah S, Blum D, Van der Hauwaert C, Scherpereel A, Cortot A, Lenain R, Maanaoui M, Pottier N, Cauffiez C, Glowacki F. Daily Caffeine Consumption May Increase the Risk of Acute Kidney Injury Related to Platinum-Salt Chemotherapy in Thoracic Cancer Patients: A Translational Study. Nutrients. 2024 Mar 19;16(6):889. doi: 10.3390/nu16060889.
  • Lionet A, Van Triempon M, Figeac M, Fages V, Gibier JB, Provot F, Maanaoui M, Pottier N, Cauffiez C, Glowacki F. Extracorporeal Photopheresis Reduces Fibrotic and Inflammatory Transcriptomic Biological Marker of Chronic Antibody-mediated Kidney Rejection. Transplant Direct. 2024 Feb 16;10(3):e1587. doi: 10.1097/TXD.0000000000001587. eCollection 2024 Mar.
  • Larrue R, Fellah S, Hennart B, Sabaouni N, Boukrout N, Van der Hauwaert C, Delage C, Cheok M, Perrais M, Cauffiez C, Allorge D, Pottier N. Integrating rare genetic variants into DPYD pharmacogenetic testing may help preventing fluoropyrimidine-induced toxicity. Pharmacogenomics. 2024 Jan 12;24(1):1.  doi: 10.1038/s41397-023-00322-x.
  • Lionet L, Van Triempon M, Figeac M, Fages V, Gibier JB, Provot F, Maanaoui M, Pottier N, Cauffiez C, Glowacki F. Extracorporeal photopheresis reduces fibrotic and inflammatory transcriptomic biological marker of chronic antibody-mediated kidney rejection. Transplant Direct. 2024 Feb 16;10(3):e1587.  doi: 10.1097/TXD.0000000000001587.
  • Larrue R, Fellah S, Boukrout N, De Sousa C, Lemaire J, Leboeuf C, Goujon M, Perrais M, Mari B, Cauffiez C, Pottier N*, Van der Hauwaert C*. miR-92a-3p regulates cisplatin-induced cancer cell death. Cell Death Dis. 2023 Sep 13;14(9):603. doi: 10.1038/s41419-023-06125-z.
  • Goy E, Martin N, Drullion C, Saas L, Molendi-Coste O, Pineau L, Dombrowicz D, Deruy E, Bauderlique-Le-Roy H, Samyn O, De Launoit Y, Abbadie C. Flow Cytometry- based Method for Efficient Sorting of Senescent Cells. Bio Protoc. 2023 Apr 5;13(7):e4612. doi: 10.21769/BioProtoc.4612.
  • Mound A, Goormachtigh G, Bray F, Flament S, Rolando C, Ruez R, Martin N, Decourcelle A, Dehennaut V, Saliou JM, Chamaillard M, Abbadie C. The NLRP6 protein is very faintly expressed in several normal and cancerous epithelial cells and may be confused with an unrelated protein. PLoS One. 2023 Jan 20;18(1):e0279028. doi: 10.1371/journal.pone.0279028.
  • Denechaud M, Geurs S, Comptdaer T, Begard S, Garcia-Núñez, Pechereau LA, Bouillet T, Vermeiren Y, de Deyn P, Perbet P, Deramecourt V, Vanderhaeghen V, Vanuytven S, Lefebvre B, Bogaert E, Deglon N, Voet T, Colin M, Buee L, Dermaut B, Galas MC. Tau promotes oxidative stress-associated cycling neurons in S phase as a pro-survival mechanism: possible implication for Alzheimer’s disease. Prog Neurobiol. 2023 Apr;223:102386. doi: 10.1016/j.pneurobio.2022.102386.
  • Dewaeles E, Carvalho K, Fellah S, Sim J, Boukrout N, Caillierez R, Ramakrishnan H, Van der Hauwaert C, Vijaya Shankara J, Martin N, Massri N, Launay A, Folger JK, de Schutter C, Larrue R, Loison I, Goujon M, Jung M, Le Gras S, Gomez-Murcia V, Faivre E, Lemaire J, Garat A, Beauval N, Maboudou P, Gnemmi V, Gibier JB, Buée L, Abbadie C, Glowacki F, Pottier N, Perrais M, Cunha RA, Annicotte JS, Laumet G, Blum D, Cauffiez C. Istradefylline protects from cisplatin-induced nephrotoxicity and peripheral neuropathy while preserving cisplatin antitumor effects. J Clin Invest. 2022 Nov 15;132(22):e152924. doi: 10.1172/JCI152924.
  • Goy E, Tomezak M, Facchin C, Martin N, Bouchaert E, Benoit J, de Schutter C, Nassour J, Saas L, Drullion C, Brodin PM, Vandeputte A, Molendi-Coste O, Pineau L, Goormachtigh G, Pluquet O, Pourtier A, Cleri F, Lartigau E, Penel N, Abbadie C. The out-of-field dose in radiation therapy induces delayed tumorigenesis by senescence evasion. Elife. 2022 Mar 18;11:e67190. doi: 10.7554/eLife.67190.
  • Goujon M, Woszczyk J, Gaudelot K, Swierczewski T, Fellah S, Gibier JB, Van Seuningen I, Larrue R, Cauffiez C, Gnemmi V, Aubert S, Pottier N, Perrais M. A Double-Negative Feedback Interaction between miR-21 and PPAR-α in Clear Renal Cell Carcinoma. Cancers (Basel). 2022 Feb 4;14(3):795. doi: 10.3390/cancers14030795.
  • Rico T, Denechaud M, Caillierez R, Comptdaer T, Adriaenssens E, Buée L, Lefebvre B.  Cancer Cells Upregulate Tau to Gain Resistance to DNA Damaging Agents. Cancers (Basel). 2022 Dec 24;15(1):116. doi: 10.3390/cancers15010116
  • Lenain R, Maanaoui M, Hamroun A, Larrue R, Van Der Hauwaert C, Gibier JB, Gnemmi V, Gomis S, Labalette M, Broly F, Hennart B, Pottier N, Hazzan M, Cauffiez C, Glowacki F. Impact of Tacrolimus Daily Dose Limitation in Renal Transplant Recipients Expressing CYP3A5: A Retrospective Study. J Pers Med. 2021 Oct 2;11(10):1002. doi: 10.3390/jpm11101002.
  • Paget S, Dubuissez M, Page A, Dehennaut V, Loison I, Spruyt N, Leprince D. Phosphorylation of HIC1 (Hypermethylated in Cancer 1) Ser694 by ATM is essential for DNA repair. Biochem Biophys Res Commun. 2021 May 14;553:51-57. doi: 10.1016/j.bbrc.2021.03.060.
  • Gibier JB, Swierczewski T, Csanyi M, Hemon B, Glowacki F, Maboudou P, Van Seuningen I, Cauffiez C, Pottier N, Aubert S, Perrais M, Gnemmi V. MUC1 Mitigates Renal Injury and Inflammation in Endotoxin-Induced Acute Kidney Injury by Inhibiting the TLR4-MD2 Axis and Reducing Pro-inflammatory Macrophages Infiltration. Shock. 2021 Oct 1;56(4):629-638. doi: 10.1097/SHK.0000000000001742.
  • Rico T, Gilles M, Chauderlier A, Comptdaer T, Magnez R, Chwastyniak M, Drobecq H, Pinet F, Thuru X, Buée L, Galas MC, Lefebvre B. Tau stabilizes chromatin compaction. Front Cell Dev Biol. 2021 Oct 14 ;9:741550 doi : 10.3389/fcell.2021.740550
  • Lemaire J, Van der Hauwaert C, Savary G, Dewaeles E, Perrais M, Lo Guidice JM, Pottier N, Glowacki F, Cauffiez C. Cadmium-Induced Renal Cell Toxicity Is Associated With MicroRNA Deregulation. Int J Toxicol. 2020 Mar/Apr;39(2):103-114. doi: 10.1177/1091581819899039.
  • Dubuissez M, Paget S, Abdelfettah S, Spruyt N, Dehennaut V, Boulay G, Loison I, de Schutter C, Rood BR, Duterque-Coquillaud M, Leroy X, Leprince D. HIC1 (Hypermethylated in Cancer 1) modulates the contractile activity of prostate stromal fibroblasts and directly regulates CXCL12 expression. Oncotarget. 2020 Nov 10;11(45):4138-4154. doi: 10.18632/oncotarget.27786.
  • Decourcelle A, Very N, Djouina M, Loison I, Thévenet J, Body-Malapel M, Lelièvre E, Coqueret O, Leprince D, El Yazidi-Belkoura I, Dehennaut V. O-GlcNAcylation Links Nutrition to the Epigenetic Downregulation of UNC5A during Colon Carcinogenesis. Cancers (Basel). 2020 Oct 28;12(11):3168. doi: 10.3390/cancers12113168.
  • Decourcelle A, Loison I, Baldini S, Leprince D, Dehennaut V. Evidence of a compensatory regulation of colonic O-GlcNAc transferase and O-GlcNAcase expression in response to disruption of O-GlcNAc homeostasis. Biochem Biophys Res Commun. 2020 Jan 1;521(1):125-130. doi: 10.1016/j.bbrc.2019.10.090.
  • Larrue R, Chamley P, Bardyn T, Lionet A, Gnemmi V, Cauffiez C, Glowacki F, Pottier N, Broly F. Diagnostic utility of whole-genome sequencing for nephronophthisis. NPJ Genom Med. 2020 Sep 21;5:38. doi: 10.1038/s41525-020-00147-8.
  • Zheng J, Akbari M, Schirmer C, Reynaert ML, Loyens A, Lefebvre B, Buée L, Croteau DL, Galas MC, Bohr VA. Hippocampal tau oligomerization early in tau pathology coincides with a transient alteration of mitochondrial homeostasis and DNA repair in a mouse model of tauopathy. Acta Neuropathol Commun. 2020 Mar 4;8(1):25 doi: 10.1186/s40478-020-00896-8.