Publications
Conti, A. G., Evans, A. C., Von Linde, T., Deguit, C. D. T., Whiteside, S. K., Wesolowski, A. J., Imianowski, C. J., Yamashita-Kanemaru, Y., Dahmani, L., Chapman, J., Pillay, A. M., Al-Deka, A., Greaves, R., Burton, O., Vardaka, P., Sampurno, S., Pérez-Núñez, I., Saw, N. Y. L., Yang, J., Mitra, S., … Roychoudhuri, R. (2026). Fine-tuning BACH2 dosage balances stemness and effector function to enhance antitumor T cell therapy. Nature Immunology. https://doi.org/10.1038/s41590-025-02389-z
Liakopoulou, A., Boussouar, F., Perazza, D., Barral, S., Lambert, E., Wang, T., Chuffart, F., Bourova-Flin, E., Gard, C., Puthier, D., Rousseaux, S., Arnoult, C., Verdel, A., & Khochbin, S. (2026). ATAD2 mediates chromatin-bound histone chaperone turnover. https://doi.org/10.7554/eLife.107582.2
Titah, S., Guillemette, A., Lewuillon, C., Shaik, F. A., Berthon, C., Goursaud, L., Tardivel, M., Bongiovanni, A., Chauvet, P., Jouy, N., Peyrouze, P., Cheok, M., Brinster, C., Manier, S., Tarhan, M. Ç., Lemonnier, L., Quesnel, B., & Touil, Y. (2026). Pre-therapeutic bone marrow-resident leukemic cells in acute myeloid leukemia exhibit a distinct dysregulated calcium signature and stem-like profile reflecting minimal residual disease precursors. Journal of Experimental & Clinical Cancer Research, 45(1), 55. https://doi.org/10.1186/s13046-025-03634-x
Chalopin, T., Cellerin, E., Demarquette, H., Pieragostini, A., Sonntag, C., Jaquet, C., De Wyngaert, Z., Rumpler, A., Roussel, M., Labouré, G., Morel, V., Vincent, L., Salle, V., Cazaubiel, T., Bobin, A., Schavgoulidze, A., Corre, J., Leleu, X., & Manier, S. (2025). Debulking strategy prior to anti-BCMA/CD3 bispecific antibodies in extramedullary and/or high tumor burden RRMM: A retrospective cohort study. Blood Cancer Journal, 15(1), 174. https://doi.org/10.1038/s41408-025-01365-y
Cheng, W., Gaggero, S., Hasan Bou Issa, L., Ouelkdite, A., Escure, G., Cozzani, A., Njosse Tchantchou, Y., Carlier, N., Wauquier, E., Decool, G., Tilmont, R., Podvin, B., Leprohon, M., Fléchon, L., Kasprowicz, A., Groux-Degroote, S., Moreaux, J., Arnulf, B., Corre, J., … Manier, S. (2025). Inflammatory microenvironment impairs the therapeutic effect of daratumumab-lenalidomide in multiple myeloma. Hematology. https://doi.org/10.1101/2025.04.23.25325569
Dhayer, M., Barral, V., Cleret, D., Jordao, A., Drucbert, A.-S., Germain, N., Dropsit, S., Maboudou, P., Dekiouk, S., Brun, S., Campagne, C., Devaux, É., Guerreschi, P., Cayla, A., & Marchetti, P. (2025). Material and biological characterization of 3D knitted bioresorbable poly (D,L-lactide) (PLA) and polycaprolactone (PCL) scaffolds for soft tissue regeneration: From fabrication to in vivo performance. Journal of Biological Engineering, 19(1), 53. https://doi.org/10.1186/s13036-025-00504-0
Gan, J., Zhang, X., & Guo, J. (2025). The role of platelets in tumor immune evasion and metastasis: Mechanisms and therapeutic implications. Cancer Cell International, 25(1), 258. https://doi.org/10.1186/s12935-025-03877-w
Manier, S., Lambert, J., Hulin, C., Macro, M., Laribi, K., Araujo, C., Pica, G. M., Touzeau, C., Godmer, P., Slama, B., Karlin, L., Orsini Piocelle, F., Dib, M., Sanhes, L., Morel, P., El Yamani, A., Tiab, M., Tabrizi, R., Richez, V., … Facon, T. (2025). Safety and efficacy of a dexamethasone-sparing regimen with daratumumab and lenalidomide in patients with frailty and newly diagnosed multiple myeloma (IFM2017-03): A phase 3, open-label, multicentre, randomised, controlled trial. The Lancet Oncology, 26(10), 1323–1333. https://doi.org/10.1016/S1470-2045(25)00280-3
Pierre, A., Favory, R., Brassart, B., Bourel, C., Romien, R., Normandin, S., Dubech, A., Vincent, C., Lemaire, J., Grolaux, G., Not, O., Wallet, F., Daussin, F., Boulanger, E., Durand, A., Frimat, M., Ghinet, A., Howsam, M., Laine, W., … Lancel, S. (2025). Sepsis Induces Long‐Term Muscle and Mitochondrial Dysfunction due to Autophagy Disruption Amenable by Urolithin A. Journal of Cachexia, Sarcopenia and Muscle, 16(4), e70041. https://doi.org/10.1002/jcsm.70041
Podvin, B., Joudinaud, R., Roumier, C., Boudry, A., Farnault, L., Dantec, M., Berthon, C., Dumezy, F., Goursaud, L., Bucci, M., Preudhomme, C., & Duployez, N. (2025). NPM1 mutation subtype switch in acute myeloid leukemia. Haematologica. https://doi.org/10.3324/haematol.2024.286916
Prod’homme, C., Bommier, C., Fenwarth, L., Moreau, S., & Polomeni, A. (2025). Cross-referencing French hematology teams’ knowledge and perception of end-of-life situations: A national mixed-methods survey. BMC Palliative Care, 24(1), 32. https://doi.org/10.1186/s12904-025-01659-9
Regnault, R., Kouach, M., Goossens, L., Thuru, X., Bailly, C., & Goossens, J. (2025). HR‐MS Analysis of the Covalent Binding of Edaravone to 5‐Formylpyrimidine Bases and a DNA Oligonucleotide Containing a 5‐Formylcytidine Residue. Rapid Communications in Mass Spectrometry, 39(14), e10050. https://doi.org/10.1002/rcm.10050
Salazar, U., Cioffi, P., Taskoparan, B., Moraga, I., Mitra, S., & Vom Berg, J. (2025). Protein engineering to overcome limitations of key cytokines in cancer immunotherapy: Current approaches and future perspectives. Immuno-Oncology and Technology, 28, 101064. https://doi.org/10.1016/j.iotech.2025.101064
Simon, V., Chuzel, C., Behal, H., Labreuche, J., Manier, S., Morschhauser, F., Pigny, P., Keller, L., Nudel, M., & Decanter, C. (2025). Is there a relationship between tumour aggressiveness and ovarian stimulation outcomes in adolescent and young adult patients with lymphoma? Reproductive BioMedicine Online, 50(3), 104448. https://doi.org/10.1016/j.rbmo.2024.104448
Sklavenitis-Pistofidis, R., Lightbody, E. D., Reidy, M., Tsuji, J., Alberge, J.-B., Aranha, M. P., Heilpern-Mallory, D., Roweth, H. G., Huynh, D., Chong, S. J. F., Chung, A. Y., Zhang, J., Hackett, L., Haradhvala, N. J., Wu, T., Su, N. K., Berrios, B., Belkin, S., Dutta, A. K., … Manier, S. (2025a). Large-scale dependency and drug screens to characterize the therapeutic vulnerabilities of multiple myeloma with 1q+. Blood, 146(1), 89–103. https://doi.org/10.1182/blood.2024025102
Vrevin, J., Lambert, M., Andrique, M., Jouy, N., & David-Cordonnier, M.-H. (2025). Direct functional HOXA9/DNA-binding competitors versus epigenetic inhibitors of HOXA9 expression on cell proliferation, death and differentiation processes in the model of MLL-rearranged acute myeloid leukemia. Investigational New Drugs, 43(4), 844–856. https://doi.org/10.1007/s10637-025-01561-4
Yang, J., Yamashita-Kanemaru, Y., Morris, B. I., Contursi, A., Trajkovski, D., Xu, J., Patrascan, I., Benson, J., Evans, A. C., Conti, A. G., Al-Deka, A., Dahmani, L., Avdic-Belltheus, A., Zhang, B., Okkenhaug, H., Whiteside, S. K., Imianowski, C. J., Wesolowski, A. J., Webb, L. V., … Roychoudhuri, R. (2025). Aspirin prevents metastasis by limiting platelet TXA2 suppression of T cell immunity. Nature, 640(8060), 1052–1061. https://doi.org/10.1038/s41586-025-08626-7
Dhayer, M., Jordao, A., Dekiouk, S., Cleret, D., Germain, N., & Marchetti, P. (2024). Implementing Chicken Chorioallantoic Membrane ( CAM ) Assays for Validating Biomaterials in Tissue Engineering: Rationale and Methods. Journal of Biomedical Materials Research Part B: Applied Biomaterials, 112(11), e35496. https://doi.org/10.1002/jbm.b.35496
Hatzfeld, A.-S., Germain, N., Maboudou, P., Dhayer, M., & Marchetti, P. (2024). Medical and economic impacts of managing corneas from older donors at the tissue bank—A single-center retrospective study spanning over 12 years. Frontiers in Medicine, 11, 1415515. https://doi.org/10.3389/fmed.2024.1415515
Ingegnere, T., Segain, B., Cozzani, A., Carlsten, M., Mitra, S., & Gaggero, S. (2024). Optimizing CAR‐NK Cell Transduction and Expansion: Leveraging Cytokine Modulation for Enhanced Performance. Current Protocols, 4(11), e70040. https://doi.org/10.1002/cpz1.70040
Leprêtre, F., Meneboo, J.-P., Villenet, C., Delestré, L., Quesnel, B., Shelley, C. S., Figeac, M., & Galiègue-Zouitina, S. (2024). Full-length RNA-Seq of the RHOH gene in human B cells reveals new exons and splicing patterns. Scientific Reports, 14(1), 28297. https://doi.org/10.1038/s41598-024-79307-0
Ziane-Chaouche, L., Raffo-Romero, A., Hajjaji, N., Kobeissy, F., Pinheiro, D., Aboulouard, S., Cozzani, A., Mitra, S., Fournier, I., Cizkova, D., Salzet, M., & Duhamel, M. (2024). Inhibition of furin in CAR macrophages directs them toward a proinflammatory phenotype and enhances their antitumor activities. Cell Death & Disease, 15(12), 879. https://doi.org/10.1038/s41419-024-07267-4
Duployez, N., Vasseur, L., Kim, R., Largeaud, L., Passet, M., L’Haridon, A., Lemaire, P., Fenwarth, L., Geffroy, S., Helevaut, N., Celli-Lebras, K., Adès, L., Lebon, D., Berthon, C., Marceau-Renaut, A., Cheok, M., Lambert, J., Récher, C., Raffoux, E., … Preudhomme, C. (2023). UBTF tandem duplications define a distinct subtype of adult de novo acute myeloid leukemia. Leukemia, 37(6), 1245–1253. https://doi.org/10.1038/s41375-023-01906-z
Escure, G., Fournier, E., Saade, C., Issa, L. H. B., Arib, I., Tilmont, R., Gazeau, N., Thiam, B. M., Chovet, M., Delforge, M., Gower, N., Fléchon, L., Cavalieri, D., Chauvet, P., Nudel, M., Goursaud, L., Berthon, C., Quesnel, B., Facon, T., … Manier, S. (2023). Small myeloid subclones are present at diagnosis of multiple myeloma in patients who develop secondary myelodysplastic syndromes. Haematologica. https://doi.org/10.3324/haematol.2023.284050
Sklavenitis-Pistofidis, R., Lightbody, E. D., Reidy, M., Tsuji, J., Aranha, M. P., Heilpern-Mallory, D., Huynh, D., Chong, S. J. F., Hackett, L., Haradhvala, N. J., Wu, T., Su, N. K., Berrios, B., Alberge, J.-B., Dutta, A., Davids, M. S., Papaioannou, M., Getz, G., Ghobrial, I. M., & Manier, S. (2023). Systematic characterization of therapeutic vulnerabilities in Multiple Myeloma with Amp1q reveals increased sensitivity to the combination of MCL1 and PI3K inhibitors. Cancer Biology. https://doi.org/10.1101/2023.08.01.551480
Duployez, N., Largeaud, L., Duchmann, M., Kim, R., Rieunier, J., Lambert, J., Bidet, A., Larcher, L., Lemoine, J., Delhommeau, F., Hirsch, P., Fenwarth, L., Kosmider, O., Decroocq, J., Bouvier, A., Le Bris, Y., Ochmann, M., Santagostino, A., Adès, L., … Sébert, M. (2022). Prognostic impact of DDX41 germline mutations in intensively treated acute myeloid leukemia patients: An ALFA-FILO study. Blood, 140(7), 756–768. https://doi.org/10.1182/blood.2021015328
Mopin, A., Leprêtre, F., Sebda, S., Villenet, C., Ben Khoud, M., Figeac, M., Quesnel, B., & Brinster, C. (2022). Detection of residual and chemoresistant leukemic cells in an immune-competent mouse model of acute myeloid leukemia: Potential for unravelling their interactions with immunity. PLOS ONE, 17(4), e0267508. https://doi.org/10.1371/journal.pone.0267508
Shaik, F. A., Lewuillon, C., Guillemette, A., Ahmadian, B., Brinster, C., Quesnel, B., Collard, D., Touil, Y., Lemonnier, L., & Tarhan, M. C. (2022). Pairing cells of different sizes in a microfluidic device for immunological synapse monitoring. Lab on a Chip, 22(5), 908–920. https://doi.org/10.1039/d1lc01156a
Trinh, A., Khamari, R., Fovez, Q., Mahon, F.-X., Turcq, B., Bouscary, D., Maboudou, P., Joncquel, M., Coiteux, V., Germain, N., Laine, W., Dekiouk, S., Jean-Pierre, S., Maguer-Satta, V., Ghesquiere, B., Idziorek, T., Quesnel, B., Kluza, J., & Marchetti, P. (2022). Antimetabolic cooperativity with the clinically approved l-asparaginase and tyrosine kinase inhibitors to eradicate CML stem cells. Molecular Metabolism, 55, 101410. https://doi.org/10.1016/j.molmet.2021.101410
Fenwarth, L., Thomas, X., de Botton, S., Duployez, N., Bourhis, J.-H., Lesieur, A., Fortin, G., Meslin, P.-A., Yakoub-Agha, I., Sujobert, P., Dumas, P.-Y., Récher, C., Lebon, D., Berthon, C., Michallet, M., Pigneux, A., Nguyen, S., Chantepie, S., Vey, N., … Itzykson, R. (2021). A personalized approach to guide allogeneic stem cell transplantation in younger adults with acute myeloid leukemia. Blood, 137(4), 524–532. https://doi.org/10.1182/blood.2020005524
Gazeau, N., Beauvais, D., Yakoub-Agha, I., Mitra, S., Campbell, T. B., Facon, T., & Manier, S. (2021). Effective anti-BCMA retreatment in multiple myeloma. Blood Advances, 5(15), 3016–3020. https://doi.org/10.1182/bloodadvances.2021004176
Itzykson, R., Fournier, E., Berthon, C., Röllig, C., Braun, T., Marceau-Renaut, A., Pautas, C., Nibourel, O., Lemasle, E., Micol, J.-B., Adès, L., Lebon, D., Malfuson, J.-V., Gastaud, L., Goursaud, L., Raffoux, E., Wattebled, K.-J., Rousselot, P., Thomas, X., … Duployez, N. (2021). Genetic identification of patients with AML older than 60 years achieving long-term survival with intensive chemotherapy. Blood, 138(7), 507–519. https://doi.org/10.1182/blood.2021011103
Bustoros, M., Sklavenitis-Pistofidis, R., Park, J., Redd, R., Zhitomirsky, B., Dunford, A. J., Salem, K., Tai, Y.-T., Anand, S., Mouhieddine, T. H., Chavda, S. J., Boehner, C., Elagina, L., Neuse, C. J., Cha, J., Rahmat, M., Taylor-Weiner, A., Van Allen, E., Kumar, S., … Ghobrial, I. M. (2020). Genomic Profiling of Smoldering Multiple Myeloma Identifies Patients at a High Risk of Disease Progression. Journal of Clinical Oncology, 38(21), 2380–2389. https://doi.org/10.1200/JCO.20.00437
Fournier, E., Duployez, N., Ducourneau, B., Raffoux, E., Turlure, P., Caillot, D., Thomas, X., Marceau-Renaut, A., Chantepie, S., Malfuson, J.-V., Lemasle, E., Cheok, M., Celli-Lebras, K., Guerin, E., Terré, C., Lambert, J., Pautas, C., Dombret, H., Castaigne, S., … Boissel, N. (2020). Mutational profile and benefit of gemtuzumab ozogamicin in acute myeloid leukemia. Blood, 135(8), 542–546. https://doi.org/10.1182/blood.2019003471
Martinez-Fabregas, J., Wang, L., Pohler, E., Cozzani, A., Wilmes, S., Kazemian, M., Mitra, S., & Moraga, I. (2020). CDK8 Fine-Tunes IL-6 Transcriptional Activities by Limiting STAT3 Resident Time at the Gene Loci. Cell Reports, 33(12), 108545. https://doi.org/10.1016/j.celrep.2020.108545
Duployez, N., Marceau-Renaut, A., Villenet, C., Petit, A., Rousseau, A., Ng, S. W. K., Paquet, A., Gonzales, F., Barthélémy, A., Leprêtre, F., Pottier, N., Nelken, B., Michel, G., Baruchel, A., Bertrand, Y., Leverger, G., Lapillonne, H., Figeac, M., Dick, J. E., … Cheok, M. (2019). The stem cell-associated gene expression signature allows risk stratification in pediatric acute myeloid leukemia. Leukemia, 33(2), 348–357. https://doi.org/10.1038/s41375-018-0227-5
Martinez-Fabregas, J., Wilmes, S., Wang, L., Hafer, M., Pohler, E., Lokau, J., Garbers, C., Cozzani, A., Fyfe, P. K., Piehler, J., Kazemian, M., Mitra, S., & Moraga, I. (2019). Kinetics of cytokine receptor trafficking determine signaling and functional selectivity. eLife, 8, e49314. https://doi.org/10.7554/eLife.49314
Itzykson, R., Duployez, N., Fasan, A., Decool, G., Marceau-Renaut, A., Meggendorfer, M., Jourdan, E., Petit, A., Lapillonne, H., Micol, J.-B., Cornillet-Lefebvre, P., Ifrah, N., Leverger, G., Dombret, H., Boissel, N., Haferlach, T., & Preudhomme, C. (2018). Clonal interference of signaling mutations worsens prognosis in core-binding factor acute myeloid leukemia. Blood, 132(2), 187–196. https://doi.org/10.1182/blood-2018-03-837781
Manier, S., Park, J., Capelletti, M., Bustoros, M., Freeman, S. S., Ha, G., Rhoades, J., Liu, C. J., Huynh, D., Reed, S. C., Gydush, G., Salem, K. Z., Rotem, D., Freymond, C., Yosef, A., Perilla-Glen, A., Garderet, L., Van Allen, E. M., Kumar, S., … Ghobrial, I. M. (2018). Whole-exome sequencing of cell-free DNA and circulating tumor cells in multiple myeloma. Nature Communications, 9(1), 1691. https://doi.org/10.1038/s41467-018-04001-5