Publications

1. Neve B, Hadj Bachir E, Duchêne B, Souidi M, Figeac M, Meneboo JP, Leteurtre E, OrgaRES consortium, Jonckheere N, Vincent A*, Van Seuningen I* Long non-coding RNA UCA1 modulates SMARCA2-containing SWI/SNF chromatin remodeling complexes in human colorectal cancer. iScience 2026; 29(1):114283. doi.org/10.1016/j.isci.2025.114283 *Equal contribution.

1. Terrassoux L, Hazard C, Laratte A, Balsamelli J, Arcicasa M, Fong E, Baland L, Soncin F, Cappello G, Maurage CA, Janel S, Bazir A, Cleri F, Treizebre A, Lartigau E, Rekik Y, Meignan S, Furlan A. Novel Diffuse Midline Glioma-on-Chip Recapitulating Tumor Biophysical Microenvironment to Assess the Heterogeneity of Response to Therapies. Small. 2025 Nov;21(45):e05343. doi: 10.1002/smll.202505343. Epub 2025 Sep 29. PMID: 41020338; PMCID: PMC12614140.

2.Ong, H.T., Karatas, E., Poquillon, T., Grenci, G., Furlan A. et al. Digitalized organoids: integrated pipeline for high-speed 3D analysis of organoid structures using multilevel segmentation and cellular topology. Nat Methods 22, 1343–1354 (2025). https://doi.org/10.1038/s41592-025-02685-4

3.Delhomelle H, Trabelsi-Grati O, Villy MC, … , Leclerc J, Bahuau M, Bièche I, Colas C. Methylation-Sensitive High-Resolution Melting technology is a simple and sensitive technique to detect germline epimutation of the MLH1 gene promoter. Clin Epigenetics. 2025 Jul 2;17(1):110. doi: 10.1186/s13148-025-01904-1. PMID: 40604912; PMCID: PMC12225165.

4. Auwercx J, Neve B, Vanlaeys A, Fourgeaud M, Bourrin-Reynard I, Souidi M, Brassart-Pasco S, Hague F, Guenin S, Duchene B, Gutierrez L, Destaing O, Dhennin-Duthille I, Van Seuningen I, Jonckheere N, Gautier M. The kinase domain of TRPM7 interacts with PAK1 and regulates pancreatic cancer cell epithelial-to-mesenchymal transition. Cell Death Dis. 2025 Apr 24;16(1):335. doi: 10.1038/s41419-025-07665-2. PMID: 40274768; PMCID: PMC12022261.

5.Ong HT, Karatas E, Poquillon T, Grenci G, Furlan A, Dilasser F, Mohamad Raffi SB, Blanc D, Drimaracci E, Mikec D, Galisot G, Johnson BA, Liu AZ, Thiel C, Ullrich O; OrgaRES Consortium; Racine V, Beghin A. Digitalized organoids: integrated pipeline for high-speed 3D analysis of organoid structures using multilevel segmentation and cellular topology. Nat Methods. 2025 May 14. doi: 10.1038/s41592-025-02685-4. Epub ahead of print. PMID: 40369245.

6.De Ponthaud C, Nassar A, Dokmak S, Bertrand T, De Martino J, Pastier C, Castel A, De Rosa R, Boubaddi M, Iben-Khayat A, Giannone F, Jolly E, Garnier J, Louis-Gaubert C, Mazzotta AD, André M, Gagnière J, Viennet M, Souche FR, Kianmanesh R, Lupinacci RM, Regimbeau JM, Paye F, Addeo P, Laurent A, Vandermeulen M, Caiazzo R, El Amrani M, Tresallet C, Doussot A, Brunel M, Jouffret L, Pinto A, Valverde A, Romero Vece R, Fara R, Mahfouf S, Darnis B, Chamakhi A, Thereaux J, Lubrano J, Girard E, Veziant J, Birnbaum DJ, Danion J, Corté H, Zemour J, Piardi T, de Carbonnières A, Ragot E, Zarzavadjian Le Bian A, David P, Brunaud L, Lermite E, Chreim L, Charlaix AL, Gugenheim J, Schwarz L, Bigourdan JM, Le Roy B, Karam E, Rhaiem R, Fabre JM, Lequeu JB, Noirault M, Ayav A, Soubrane O, Regenet N, Turrini O, Muscari F, Pessaux P, Thébault B, Laurent C, Sulpice L, Sauvanet A, Fuks D, Gaujoux S; AFC- study group. Conversion during Minimally Invasive Left Pancreatectomy. A Nationwide Study of Causes and Consequences. Ann Surg. 2025 Feb 28. doi. 10.1097/SLA.0000000000006685. Epub ahead of print. PMID. 40018739.

7.Meynard T, Royer F, Houssier R, Bajeux O, Paget S, Lahdaoui F, Mogrovejo Valdivia A, Maubon N, Vicogne J, Van Seuningen I, Senez V. Fabrication of a bioreactor combining soft lithography and vat photopolymerisation to study tissues and multicellular organisms under dynamic culture conditions. Lab Chip. 2025 Aug 5;25(16):4119-4137. doi: 10.1039/d5lc00172b. PMID: 40667579.

1.Weiswald L.B., Thorel L., Perréard M., Florent M., Divoux J., Vincent A., Gaggioli C., Guasch G., Poulain L., Gidrol W., Coffy S. Patient-derived tumor organoids: a new avenue for preclinical research and precision medicine in oncology. Exp Mol Med 56, 1531–1551 (2024). https://doi.org/10.1038/s12276-024-01272-5

2.Loison I, Pioger A, Paget S, Metatla I, Vincent A, Abbadie C, Dehennaut V. O-GlcNAcylation inhibition redirects the response of colon cancer cells to chemotherapy from senescence to apoptosis. Cell Death Dis. 2024 Oct 19;15(10):762. doi: 10.1038/s41419-024-07131-5. PMID: 39426963; PMCID: PMC11490504.

3.Kasprowicz A, Cavdarli S, Delannoy P, Le Guezennec X, Defebvre C, Spriet C, Jonckheere N, Le Doussal Jm, Krzewinski-Recchi Ma, Mitra S, Meignan S, Groux- Degroote S. Anti-OAcGD2 antibody in combination with ceramide kinase inhibitor mediate potent antitumor cytotoxicity against breast cancer and diffuse intrinsic pontine glioma cells. Mol Cell Biochem. 2025 Apr;480(4):2555-2571. doi: 10.1007/s11010-024-05127-5. Epub 2024 Oct 12. PMID: 39395135.

4.Huchede P, Meyer S, Berthelot C, Hamadou M, Bertrand-Chapel A, Rakotomalala A, Manceau L, Tomine J, Lespinasse N, Lewandowski P, Cordier-Bussat M, Broutier L, Dutour A, Rochet I, Blay JY, Degletagne C, Attignon V, Montero-Carcaboso A, Le Grand M, Pasquier E, Vasiljevic A, Gilardi-Hebenstreit P, Meignan S, Leblond P, Ribes V, Cosset E, Castets M. BMP2 and BMP7 cooperate with H3.3K27M to promote quiescence and invasiveness in pediatric diffuse midline gliomas. Elife. 2024 Oct 7;12:RP91313. doi: 10.7554/eLife.91313. PMID: 39373720; PMCID: PMC11458179.

5.Laguillaumie MO, Titah S, Guillemette A, Neve B, Leprêtre F, Ségard P, Shaik FA, Collard D, Gerbedoen JC, Fléchon L, Hasan Bou Issa L, Vincent A, Figeac M, Sebda S, Villenet C, Kluza J, Laine W, Fournier I, Gimeno JP, Wisztorski M, Manier S, Tarhan MC, Quesnel B, Idziorek T, Touil Y. Deciphering genetic and nongenetic factors underlying tumour dormancy: insights from multiomics analysis of two syngeneic MRD models of melanoma and leukemia. Biol Res. 2024 Sep 3;57(1):59. doi: 10.1186/s40659-024-00540-y. PMID: 39223638; PMCID: PMC11370043.

6.Rouault A, Richa Y, El Amrani M. Feasibility and outcomes of robotic partial pancreatoduodenectomy. Hepatobiliary Surg Nutr. 2024 Aug 1;13(4).669-671. doi. 10.21037/hbsn-24-288. Epub 2024 Jul 16. PMID. 39175737; PMCID. PMC11336533.

7.PancreasGroup.org Collaborative. Pancreatic surgery outcomes. Multicentre prospective snapshot study in 67 countries. Br J Surg. 2024 Jan 3;111(1).znad330. doi. 10.1093/bjs/znad330. PMID. 38743040; PMCID. PMC10771125.

8.Roth GS, Verlingue L, Sarabi M, Blanc JF, Boleslawski E, Boudjema K, Bretagne-Bignon AL, Camus-Duboc M, Coriat R, Créhange G, De Baere T, de la Fouchardière C, Dromain C, Edeline J, Gelli M, Guiu B, Horn S, Laurent-Croise V, Lepage C, Lièvre A, Lopez A, Manfredi S, Meilleroux J, Neuzillet C, Paradis V, Prat F, Ronot M, Rosmorduc O, Cunha AS, Soubrane O, Turpin A, Louvet C, Bouché O, Malka D. Biliary tract cancers. French national clinical practice guidelines for diagnosis, treatments and follow-up (TNCD, SNFGE, FFCD, UNICANCER, GERCOR, SFCD, SFED, AFEF, SFRO, SFP, SFR, ACABi, ACHBPT). Eur J Cancer. 2024 May;202.114000. doi. 10.1016/j.ejca.2024.114000. Epub 2024 Mar 13. PMID.38493667.

9.Gaujoux S, Regimbeau JM, Piessen G, Truant S, Foissac F, Barbier L, Buc E, Adham M, Fuks D, Deguelte S, Muscari F, Sulpice L, Vaillant JC, Schwarz L, Sa Cunha A, Muzzolini M, Dousset B, Sauvanet A; Collaborators. Somatostatin Versus Octreotide for Prevention of Postoperative Pancreatic Fistula. The PREFIPS Randomized Clinical Trial. A FRENCH 007-ACHBT Study. Ann Surg. 2024 Aug 1;280(2).179-187. doi. 10.1097/SLA.0000000000006313. Epub 2024 Apr 25. PMID. 38662619.

10.Kusamura S, Bhatt A, van Der Speeten K, Kepenekian V, Hübner M, Eveno C, de Hingh I, Delhorme JB, Taibi A, Villeneuve L, Dico RL, Moran B, Govaerts K, Zivanovic O, Brennan D, Nadeau C, Van Driel W, Bakrin N, Piso P, Verwaal VJ, González-Moreno S, Alyami M, Sgarbura O, Rau B, Deraco M, Glehen O. Review of 2022 PSOGI/RENAPE Consensus on HIPEC. J Surg Oncol. 2024 Nov;130(6).1290-1298. doi. 10.1002/jso.27885. Epub 2024 Sep 16. PMID. 39285659; PMCID. PMC11826010.

1. Fournier M, Leclerc P, Leray A, Champelovier D, Agbazahou F, Dahmani F, Bidaux G, Furlan A*, Héliot L.* Combined SPT and FCS methods reveal a mechanism of RNAP II oversampling in cell nuclei. Scientific Reports 2023; 13(1):14633. doi: 10.1038/s41598-023-38668-8. *Equal contribution.

2. Turpin A, Delliaux C, Parent P, Chevalier H, Escudero-Iriarte C, Bonardi F, Vanpouille N, Flourens A, Querol J, Carnot A, Leroy X, Herranz N, Lanel T, Villers A, Olivier J, Touzet H, de Launoit Y, Tian TV, Duterque-Coquillaud M. Fascin-1 expression is associated with neuroendocrine prostate cancer and directly suppressed by androgen receptor Br J Cancer. 2023 Oct 24. doi: 10.1038/s41416-023-02449-x. Online ahead of print.

3. Marchese U, Desbiens JF, Lenne X, Naveendran G, Tzedakis S, Gaillard M, Bruandet A, Theis D, Boyer L, Truant S, Fuks D, El Amrani M. Study of Risk Factors for Readmission After Pancreatectomy for Cancer: Analysis of Nationwide Cohort Ann Surg. 2023 May 31. doi: 10.1097/SLA.0000000000005929. Online ahead of print.

4. Turpin A, Descarpentries C, Grégoire V, Farchi O, Cortot AB, Jamme P. Response to Capmatinib in a MET Fusion-positive Cholangiocarcinoma Oncologist. 2023 Jan 18;28(1):80-83. doi: 10.1093/oncolo/oyac194.

1. Leclerc J, Beaumont M, Vibert R, Pinson S, Vermaut C, Flament C, Lovecchio T, Delattre L, Demay C, Coulet F, Guillerm E, Hamzaoui N, Benusiglio PR, Brahimi A, Cornelis F, Delhomelle H, Fert-Ferrer S, Fournier BPJ, Hovnanian A, Legrand C, Lortholary A, Malka D, Petit F, Saurin JC, Lejeune S, Colas C, Buisine MP. AXIN2 germline testing in a French cohort validates pathogenic variants as a rare cause of predisposition to colorectal polyposis and cancer Genes Chromosomes Cancer. 2023 Apr;62(4):210-222. doi: 10.1002/gcc.23112. Epub 2022 Dec 21.

2. Durin T, Marchese U, Sauvanet A, Dokmak S, Cherkaoui Z, Fuks D, Laurent C, André M, Ayav A, Magallon C, Turrini O, Sulpice L, Robin F, Bachellier P, Addeo P, Souche FR, Bardol T, Perinel J, Adham M, Tzedakis S, Birnbaum DJ, Facy O, Gagniere J, Gaujoux S, Tribillon E, Roussel E, Schwarz L, Barbier L, Doussot A, Regenet N, Iannelli A, Regimbeau JM, Piessen G, Lenne X, Truant S, El Amrani M. Defining Benchmark Outcomes for Distal Pancreatectomy: Results of a French Multicentric Study Ann Surg. 2022 Jul 1;278(1):103-109. doi: 10.1097/SLA.0000000000005539. Epub 2022 Jun 28.

3. Bancel LP, Masso V, Dessein AF, Aubert S, Leteurtre E, Coppin L, Odou MF, Do Cao C, Cardot-Bauters C, Pigny P. Serum succinate/fumarate ratio in paraganglioma/pheochromocytoma patients attending an endocrine oncogenetic unit J Clin Endocrinol Metab. 2023 Feb 27:dgad109. doi: 10.1210/clinem/dgad109. Online ahead of print.

1. Hadj Bachir E*, Poiraud C*, Paget S, Stoup N, El Moghrabi S, Duchêne B, Jouy N, Bongiovanni A, Tardivel M, Weiswald LB, Vandepeutte M, Beugniez C, Escande F, Leteurtre E; OrgaRES consortium; Poulain L, Lagadec C, Pigny P, Jonckheere N, Renaud F, Truant S, Van Seuningen I*, Vincent A*. A new pancreatic adenocarcinoma-derived organoid model of acquired chemoresistance to FOLFIRINOX: First insight of the underlying mechanisms Biol Cell. 2022 Jan;114(1):32-55. doi: 10.1111/boc.202100003. Epub 2021 Oct 16. *Equal contribution

2. Rakotomalala A, Bailleul Q, Savary C, Arcicasa M, Hamadou M, Huchedé P, Hochart A, Restouin A, Castellano R, Collette Y, Dieny E, Vincent A, Angrand PO, Le Bourhis X, Leblond P, Furlan A, Castets M, Pasquier E, Meignan S. H3.3K27M Mutation Controls Cell Growth and Resistance to Therapies in Pediatric Glioma Cell Lines Cancers (Basel). 2021 Nov 5;13(21):5551. doi: 10.3390/cancers13215551.

3. Bailleul Q, Navarin P, Arcicasa M, Bal-Mahieu C, Carcaboso AM, Le Bourhis X, Furlan A, Meignan S, Leblond P. Evofosfamide Is Effective against Pediatric Aggressive Glioma Cell Lines in Hypoxic Conditions and Potentiates the Effect of Cytotoxic Chemotherapy and Ionizing Radiations Cancers (Basel). 2021 Apr 9;13(8):1804. doi: 10.3390/cancers13081804.

4. Bauzone M*, Souidi M*, Dessein AF, Wisztorski M, Vincent A, Gimeno JP, Monté D, Van Seuningen I, Gespach C, Huet G. Cross-talk between YAP and RAR-RXR Drives Expression of Stemness Genes to Promote 5-FU Resistance and Self-Renewal in Colorectal Cancer Cells Mol Cancer Res. 2021 Apr;19(4):612-622. doi: 10.1158/1541-7786.MCR-20-0462. Epub 2021 Jan 20.

5. El Amrani M, Clement G, Lenne X, Turpin A, Valibouze C, Rogosnitzky M, Theis D, Pruvot FR, Zerbib P. Failure to rescue following proctectomy for rectal cancer: the additional benefit of laparoscopic approach in a nationwide observational study of 44,536 patients Surg Endosc. 2022 Jan;36(1):435-445. doi: 10.1007/s00464-021-08303-6. Epub 2021 Apr 19.

6. Bortolotti, P ; Delpierre, C ; Le Guern, R ; Kipnis, E ; Lebuffe, G ; Lenne, X … El Amrani, M. High incidence of postoperative infections after pancreaticoduodenectomy: A need for perioperative anti-infectious strategies. Infect Dis Now 2021 doi: 10.1016/j.idnow.2021.01.001.

7. Beugniez C, Sauvanet A, Sulpice L, Gaujoux S, Turrini O, Truant S, Schwarz L, Piessen G, Regimbeau JM, Muscari F, Adham M, Pattou F, Schneider L, Clement G, Delpero JR, Pruvot FR, El Amrani M; French-ACHBT Working Group. Root-cause Analysis of Mortality After Pancreatic Resection (CARE Study): A Multicenter Cohort Study. Ann Surg. 2021 Nov 1;274(5):789-796. doi: 10.1097/SLA.0000000000005118.

8. Chebaro A, Buc E, Durin T, Chiche L, Brustia R, Didier A, Pruvot FR, Kitano Y, Muscari F, Lecolle K, Sulpice L, Sonmez E, Bougard M, El Amrani M, Sommacale D, Maulat C, Ayav A, Adam R, Laurent C, Truant S. Liver Venous Deprivation or Associating Liver Partition and Portal Vein Ligation for Staged Hepatectomy?: A Retrospective Multicentric Study Ann Surg. 2021 Nov 1;274(5):874-880. doi: 10.1097/SLA.0000000000005121.

9. Decanter C, Delepine J, Behal H, Manier S, Bruno B, Barbatti M, Robin C, Labreuche J, Morschhauser F, Pigny P. Longitudinal study of AMH variations in 122 Adolescents and Young Adults (AYA) and non-AYA lymphoma patients to evaluate the chemo-induced ovarian toxicity to further personalize fertility preservation counselling. Hum Reprod., 36(10):2743-2752 (2021).

10. Marchese U, Fuks D, Truant S, El Amrani M. Comment on: Failure to rescue in patients with distal pancreatectomy: a nationwide analysis of 10,632 patients Hepatobiliary Surg Nutr. 2021 Apr;10(2):229-231. doi: 10.21037/hbsn-21-105.

11. Khodr J, Truant S, El Amrani M. Surgical ampullectomy with resection of the common bile duct for biliary papillomatosis J Gastrointest Surg. 2021 Apr;25(4):1087-1088. doi: 10.1007/s11605-020-04851-9. Epub 2020 Nov 25.

12. Vauléon, E., Behal, H., Lebellec, L., Desbarbieux, R., Baldacci, S., Simon, N., Pannier, D., Vieillard, MH., Turpin, A. Does bevacizumab increase joint pain in patients with cancer? Results of the prospective observational BEVARTHRALGIA study. Cancer Chemother Pharmacol. 2021. https://doi.org/10.1007/s00280-020-04226-6

13. Neve B, Jonckheere N, Vincent A, Van Seuningen I. Long non-coding RNAs: the tentacles of chromatin remodeler complexes Cell Mol Life Sci. 2021 Feb;78(4):1139-1161. doi: 10.1007/s00018-020-03646-0. Epub 2020 Oct 1.

14. Bailleul Q, Rakotomalala A, Ferry I, Leblond P, Meignan S, Furlan A. [The art of war as applied to pediatric gliomas: Know your enemy] Med Sci (Paris). 2021 Feb;37(2):159-166. doi: 10.1051/medsci/2020279. Epub 2021 Feb 16.

15. Vincent A, Delacour D, Pigny P. [Galectin-3, an unexpected mediator at the ER-mitochondria negotiating table] Med Sci (Paris). 2021 Jun-Jul;37(6-7):569-571. doi: 10.1051/medsci/2021066. Epub 2021 Jun 28.

16. Vamecq J, Pigny P. Emerging considerations on mitochondrial and cytosolic metabolic features in SDH-deficient cancer cells Mol Genet Metab Rep. 2021 Feb 2;26:100721. doi: 10.1016/j.ymgmr.2021.100721. eCollection 2021 Mar.

17. Rakotomalala A, Escande A, Furlan A, Meignan S, Lartigau E. Hypoxia in Solid Tumors: How Low Oxygenation Impacts the "Six Rs" of Radiotherapy Front Endocrinol (Lausanne). 2021 Sep 2;12:742215. doi: 10.3389/fendo.2021.742215. eCollection 2021.

18. Leclerc J, Vermaut C, Buisine MP. Diagnosis of Lynch Syndrome and Strategies to Distinguish Lynch-Related Tumors from Sporadic MSI/dMMR Tumors Cancers (Basel). 2021 Jan 26;13(3):467. doi: 10.3390/cancers13030467.

19. Truant S, Baillet C, Gnemmi V, Fulbert M, Turpin A, Dardenne S, Leteurtre E, El Amrani M, Dharancy S, Dubuquoy L, Huglo D, Chesné C, Pruvot FR. The Impact of Modern Chemotherapy and Chemotherapy-Associated Liver Injuries (CALI) on Liver Function: Value of 99mTc-Labelled-Mebrofenin SPECT-Hepatobiliary Scintigraphy Ann Surg Oncol. 2021 Apr;28(4):1959-1969. doi: 10.1245/s10434-020-08988-4. Epub 2020 Aug 24.

20. Vary A, Lebellec L, Di Fiore F, Penel N, Cheymol C, Rad E, El Hajbi F, Lièvre A, Edeline J, Bimbai AM, Le Deley MC, Turpin A. FOLFIRINOX relative dose intensity and disease control in advanced pancreatic adenocarcinoma Ther Adv Med Oncol. 2021 Jul 16;13:17588359211029825. doi: 10.1177/17588359211029825. eCollection 2021.

21. Truant S. Enlarged and uncommon indications for ALPPS-where do we stand? Hepatobiliary Surg Nutr. 2022 Oct;11(5):743-745. doi: 10.21037/hbsn-22-371.

22. Turpin A, El Amrani M, Zaanan A. Localized Small Bowel Adenocarcinoma Management: Evidence Summary Cancers (Basel). 2022 Jun 11;14(12):2892. doi: 10.3390/cancers14122892.

23. Turpin A, Neuzillet C, Colle E, Dusetti N, Nicolle R, Cros J, de Mestier L, Bachet JB, Hammel P. Therapeutic advances in metastatic pancreatic cancer: a focus on targeted therapies Ther Adv Med Oncol. 2022 Sep 6;14:17588359221118019. doi: 10.1177/17588359221118019. eCollection 2022.

24. Bridoux M, Simon N, Turpin A. Proton Pump Inhibitors and Cancer: Current State of Play Front Pharmacol. 2022 Mar 14;13:798272. doi: 10.3389/fphar.2022.798272. eCollection 2022.

25. Pigny P. Translational research in neuroendocrine tumors (NETs): What's new in 2021? Ann Endocrinol (Paris). 2022 Dec;83(6):469-471. doi: 10.1016/j.ando.2022.09.001. Epub 2022 Oct 3.

26. Vamecq J, Masso V, Bancel LP, Jannin A, Dessein AF, Cardot-Bauters C, Pigny P. Serum fatty acid profiling in patients with SDHx mutations: New advances on cellular metabolism in SDH deficiency Biochimie. 2022 Oct;201:196-203. doi: 10.1016/j.biochi.2022.07.008. Epub 2022 Jul 21.