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Sarr S, Godard J, Valzer E, Czuba E, Acherar S, Barberi-Heyob M, Blanchard-Desce M, Boleslawski E, Brégier F, Bulin AL, Burckel H, Daouk J, da Silva A, Daniel J, Delhem N, Dewalle AS, Frochot C, Gasser G, Heitz V, Jonckheere N, Lemercier G, Mordon S, Noël G, Novell A, Ravanat JL, Roth G, Sol V. Targeted photodynamic therapy for pancreatic cancer: recent innovations from fundamentals to <i>in vivo</i> and clinical applications (2020-2025). Chem Commun (Camb). 2026 Feb 12;62(12):3662-3701. doi: 10.1039/d5cc05629b. PMID: 41568579.
Meynard T, Royer F, Houssier R, Bajeux O, Paget S, Lahdaoui F, Mogrovejo Valdivia A, Maubon N, Vicogne J, Van Seuningen I, Senez V. Fabrication of a bioreactor combining soft lithography and vat photopolymerisation to study tissues and multicellular organisms under dynamic culture conditions.Lab Chip. 2025 Aug 5;25(16):4119-4137. doi: 10.1039/d5lc00172b. PMID: 40667579.
Neve B, Hadj Bachir E, Duchêne B, Souidi M, Figeac M, Meneboo JP, Leteurtre E; OrgaRES Consortium; Jonckheere N, Vincent A, Van Seuningen I. Long non-codingRNA UCA1 modulates SMARCA2-containing SWI/SNF chromatin remodeling complexes in human colorectal cancer.iScience. 2025 Nov 29;29(1):114283. doi: 10.1016/j.isci.2025.114283. PMID: 41537001; PMCID: PMC12796597.
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Laîné M, Guénin S, Gutierrez L, Dehouck MP, Jonckheere N, Gosselet F, Toillon RA, Mysiorek C, Ouadid-Ahidouch H, Girault A. The Kv10.1 potassium channel, driver of hypoxia-induced EMT and breast cancer cell aggressiveness. Cancer Cell Int. 2025 Oct 24;25(1):373. doi: 10.1186/s12935-025-04020-5. PMID: 41340125; PMCID: PMC12673720.
Sandoval Pacheco C, Leroy AM, Derhourhi M, Cardon T, Leroy C, Jouy N, Com E, Guevel B, Bourette R, Carrard J, Barros D, Duchêne B, Toussaint B, Froguel P, Jonckheere N, Chassat T, Van Seuningen I, Lavigne R, Pineau C, Pierre P, Soncin F, Salzet M, Bonnefond A, Lejeune F. Exploring the role of readthrough-inducing molecule 2,6-diaminopurine to increase immune response against cancer cells.Mol Ther. 2025 Dec 3;33(12):6212-6225. doi: 10.1016/j.ymthe.2025.09.024. Epub 2025 Sep 12. PMID: 40946162; PMCID: PMC12703180.
Auwercx J, Neve B, Vanlaeys A, Fourgeaud M, Bourrin-Reynard I, Souidi M, Brassart-Pasco S, Hague F, Guenin S, Duchene B, Gutierrez L, Destaing O, Dhennin-Duthille I, Van Seuningen I, Jonckheere N, Gautier M. The kinase domain of TRPM7 interacts with PAK1 and regulates pancreatic cancer cell epithelial-to-mesenchymal transition. Cell Death Dis. 2025 Apr 24;16(1):335. doi: 10.1038/s41419-025-07665-2. PMID: 40274768; PMCID: PMC12022261.
Bernhard C, Geles K, Pawlak G, Dhifli W, Dispot A, Dusol J, Kondratova M, Martin S, Messé M, Reita D, Tulasne D, Van Seuningen I, Entz-Werle N, Ciafrè SA, Dontenwill M, Elati M. A coregulatory influence map of glioblastoma heterogeneity and plasticity.NPJ Precis Oncol. 2025 Apr 15;9(1):110. doi: 10.1038/s41698-025-00890-0. PMID: 40234567; PMCID: PMC12000621.
Jannin A, Dabo-Niang S, Do Cao C, Descat A, Espiard S, Cardot-Bauters C, Vantyghem MC, Chevalier B, Goossens JF, Marsac B, Vandel J, Dominguez S, Caiazzo R, Pattou F, Marciniak C, El Amrani M, Van Seuningen I, Jonckheere N, Dessein AF, Coppin L. Identification of metabolite biomarkers for pancreatic neuroendocrine tumours using a metabolomic approach. Eur J Endocrinol. 2025 Mar 27;192(4):466-480. doi: 10.1093/ejendo/lvaf055. PMID: 40105057.
Kasprowicz A, Cavdarli S, Delannoy P, Le Guezennec X, Defebvre C, Spriet C, Jonckheere N, Le Doussal JM, Krzewinski-Recchi MA, Mitra S, Meignan S, Groux- Degroote S. Anti-OAcGD2 antibody in combination with ceramide kinase inhibitor mediates potent antitumor cytotoxicity against breast cancer and diffuse intrinsic pontine glioma cells.Mol Cell Biochem. 2025 Apr;480(4):2555-2571. doi: 10.1007/s11010-024-05127-5. Epub 2024 Oct 12. PMID: 39395135.
Auwercx J, Fourgeaud M, Lalot A, Gautier M. Unraveling the Connection Between Ion Channels and Pancreatic Stellate Cell Activation.Cell Physiol Biochem. 2025 Jan 18;59(S1):25-40. doi: 10.33594/000000754. PMID: 39825736.
Loison I, Pioger A, Paget S, Metatla I; OrgaRES Consortium; Vincent A, Abbadie C, Dehennaut V. O-GlcNAcylation inhibition redirects the response of colon cancer cells to chemotherapy from senescence to apoptosis.Cell Death Dis. 2024 Oct 19;15(10):762. doi: 10.1038/s41419-024-07131-5. PMID: 39426963; PMCID: PMC11490504.
Stoup N, Liberelle M, Lebègue N, Van Seuningen I. Emerging paradigms and recent progress in targeting ErbB in cancers. Trends Pharmacol Sci. 2024 Jun;45(6):552-576. doi: 10.1016/j.tips.2024.04.009. Epub 2024 May 25. PMID: 38797570.
Nussinov R, Weichhart T, Dlamini Z, Gibbons DL, Van Seuningen I, Konen J, Ju HQ. Directions to overcome therapy resistance in cancer. Trends Pharmacol Sci. 2024 Jun;45(6):467-471. doi: 10.1016/j.tips.2024.05.001. Epub 2024 May 16. PMID: 38760267.
Du Q, Yu Z, Zhang Z, Yang J, Jonckheere N, Shi S, Wang W, Xu J, Liu J, Yu X. Identification of pancreatic adenocarcinoma immune subtype associated with tumor neoantigen from aberrant alternative splicing. J Gastrointest Oncol. 2024 Jun 30;15(3):1179-1197. doi: 10.21037/jgo-24-340. Epub 2024 Jun 27. PMID: 38989416; PMCID: PMC11231849.
Bourdon E, Swierczewski T, Goujon M, Boukrout N, Fellah S, Van der Hauwaert C, Larrue R, Lefebvre B, Van Seuningen I, Cauffiez C, Pottier N, Perrais M. MUC1 Drives the Progression and Chemoresistance of Clear Cell Renal Carcinomas. Cancers (Basel). 2024 Jan 17;16(2):391. doi: 10.3390/cancers16020391. PMID: 38254882; PMCID: PMC10814283.
Quilbe A, Mustapha R, Duchêne B, Kumar A, Werkmeister E, Leteurtre E, Moralès O, Jonckheere N, Van Seuningen I, Delhem N. A novel anti-galectin-9 immunotherapy limits the early progression of pancreatic neoplastic lesions in transgenic mice. Front Immunol. 2023 Nov 30;14:1267279. doi: 10.3389/fimmu.2023.1267279. PMID: 38098486; PMCID: PMC10720041.
Cicero J, Trouvilliez S, Palma M, Ternier G, Decoster L, Happernegg E, Barois N, Van Outryve A, Dehouck L, Bourette RP, Adriaenssens E, Lagadec C, Tarhan CM, Collard D, Souguir Z, Vandenhaute E, Maubon G, Sipieter F, Borghi N, Shimizu F, Kanda T, Giacobini P, Gosselet F, Maubon N, Le Bourhis X, Van Seuningen I, Mysiorek C, Toillon RA. ProNGF promotes brain metastasis through TrkA/EphA2 induced Src activation in triple negative breast cancer cells. Exp Hematol Oncol. 2023 Dec 10;12(1):104. doi: 10.1186/s40164-023-00463-6. PMID: 38072918; PMCID: PMC10710730.
Jannin A, Dessein AF, Do Cao C, Vantyghem MC, Chevalier B, Van Seuningen I, Jonckheere N, Coppin L. Metabolism of pancreatic neuroendocrine tumors: what can omics tell us?Front Endocrinol (Lausanne). 2023 Oct 16;14:1248575. doi: 10.3389/fendo.2023.1248575. PMID: 37908747; PMCID: PMC10613989.
Auwercx J, Kischel P, Lefebvre T, Jonckheere N, Vanlaeys A, Guénin S, Radoslavova S, Van Seuningen I, Ouadid-Ahidouch H, Kocher HM, Dhennin-Duthille I, Gautier M. TRPM7 Modulates Human Pancreatic Stellate Cell Activation. Cells. 2022 Jul 21;11(14):2255. doi: 10.3390/cells11142255. PMID: 35883700; PMCID: PMC9316618.
Foulon A, Rybarczyk P, Jonckheere N, Brabencova E, Sevestre H, Ouadid- Ahidouch H, Rodat-Despoix L. Inositol (1,4,5)-Trisphosphate Receptors in Invasive Breast Cancer: A New Prognostic Tool? Int J Mol Sci. 2022 Mar 9;23(6):2962. doi: 10.3390/ijms23062962. PMID: 35328381; PMCID: PMC8955728.
Raab S, Very N, Duchêne B, Rybarczyk P, Jonckheere N, El Yazidi-Belkoura I, Lefebvre T. Evaluation of the expression of fatty acid synthase and <i>O</i>-GlcNAc transferase in patients with liver cancer by exploration of transcriptome databases and experimental approaches. Oncol Lett. 2022 Apr;23(4):105. doi: 10.3892/ol.2022.13225. Epub 2022 Feb 3. PMID: 35242233; PMCID: PMC8848257.
Goujon M, Woszczyk J, Gaudelot K, Swierczewski T, Fellah S, Gibier JB, Van Seuningen I, Larrue R, Cauffiez C, Gnemmi V, Aubert S, Pottier N, Perrais M. A Double-Negative Feedback Interaction between miR-21 and PPAR-α in Clear Renal Cell Carcinoma. Cancers (Basel). 2022 Feb 4;14(3):795. doi: 10.3390/cancers14030795. PMID: 35159062; PMCID: PMC8834244.
Gautier M, Vandier C. Orai1/KCa/SigmaR1 complex, the cancer cell suicide squad.Cell Calcium. 2022 Jun;104:102568. doi: 10.1016/j.ceca.2022.102568. Epub 2022 Feb 28. PMID: 35248794.
Radoslavova S, Folcher A, Lefebvre T, Kondratska K, Guénin S, Dhennin- Duthille I, Gautier M, Prevarskaya N, Ouadid-Ahidouch H. Orai1 Channel Regulates Human-Activated Pancreatic Stellate Cell Proliferation and TGF<sub>β1</sub> Secretion through the AKT Signaling Pathway. Cancers (Basel). 2021 May 15;13(10):2395. doi: 10.3390/cancers13102395. PMID: 34063470; PMCID: PMC8156432.
Boukrout N, Souidi M, Lahdaoui F, Duchêne B, Neve B, Coppin L, Leteurtre E, Torrisani J, Van Seuningen I, Jonckheere N. Antagonistic Roles of the Tumor Suppressor miR-210-3p and Oncomucin MUC4 Forming a Negative Feedback Loop in Pancreatic Adenocarcinoma. Cancers (Basel). 2021 Dec 9;13(24):6197. doi: 10.3390/cancers13246197. PMID: 34944818; PMCID: PMC8699468.
Kumemura M, Pekin D, Menon VA, Van Seuningen I, Collard D, Tarhan MC. Silicon Resonators for Analysing Biological Samples. Micromachines (Basel). 2021 Dec 12;12(12):1546. doi: 10.3390/mi12121546. PMID: 34945396; PMCID: PMC8708134.
Stoup N, Liberelle M, Schulz C, Cavdarli S, Vasseur R, Magnez R, Lahdaoui F, Skrypek N, Peretti F, Frénois F, Thuru X, Melnyk P, Renault N, Jonckheere N, Lebègue N, Van Seuningen I. The EGF Domains of MUC4 Oncomucin Mediate HER2 Binding Affinity and Promote Pancreatic Cancer Cell Tumorigenesis. Cancers (Basel). 2021 Nov 16;13(22):5746. doi: 10.3390/cancers13225746. PMID: 34830899; PMCID: PMC8616066.
Raby L, Völkel P, Hasanpour S, Cicero J, Toillon RA, Adriaenssens E, Van Seuningen I, Le Bourhis X, Angrand PO. Loss of Polycomb Repressive Complex 2 Function Alters Digestive Organ Homeostasis and Neuronal Differentiation inZebrafish. Cells. 2021 Nov 12;10(11):3142. doi: 10.3390/cells10113142. PMID:34831364; PMCID: PMC8620594.
Hadj Bachir E, Poiraud C, Paget S, Stoup N, El Moghrabi S, Duchêne B, Jouy N, Bongiovanni A, Tardivel M, Weiswald LB, Vandepeutte M, Beugniez C, Escande F, Leteurtre E; OrgaRES consortium; Poulain L, Lagadec C, Pigny P, Jonckheere N, Renaud F, Truant S, Van Seuningen I, Vincent A. A new pancreatic adenocarcinoma-derived organoid model of acquired chemoresistance to FOLFIRINOX: First insight of the underlying mechanisms.Biol Cell. 2022 Jan;114(1):32-55. doi: 10.1111/boc.202100003. Epub 2021 Oct 16. PMID: 34561874.
Jonckheere N, Vincent A, Neve B, Van Seuningen I. Mucin expression, epigenetic regulation and patient survival: A toolkit of prognostic biomarkersin epithelial cancers. Biochim Biophys Acta Rev Cancer. 2021 Aug;1876(1):188538. doi: 10.1016/j.bbcan.2021.188538. Epub 2021 Apr 20. PMID: 33862149.
Wavelet-Vermuse C, Groux-Degroote S, Vicogne D, Cogez V, Venturi G, Trinchera M, Brysbaert G, Krzewinski-Recchi MA, Hadj Bachir E, Schulz C, Vincent A, Van Seuningen I, Harduin-Lepers A. Analysis of the proximal promoter of the human colon-specific B4GALNT2 (Sd<sup>a</sup> synthase) gene: B4GALNT2 is transcriptionally regulated by ETS1. Biochim Biophys Acta Gene Regul Mech. 2021 Nov-Dec;1864(11-12):194747. doi: 10.1016/j.bbagrm.2021.194747. Epub 2021 Sep 7. PMID: 34500083.
Gibier JB, Swierczewski T, Csanyi M, Hemon B, Glowacki F, Maboudou P, Van Seuningen I, Cauffiez C, Pottier N, Aubert S, Perrais M, Gnemmi V. MUC1 Mitigates Renal Injury and Inflammation in Endotoxin-Induced Acute Kidney Injury by Inhibiting the TLR4-MD2 Axis and Reducing Pro-inflammatory Macrophages Infiltration. Shock. 2021 Oct 1;56(4):629-638. doi: 10.1097/SHK.0000000000001742. PMID: 33534395.
Bauzone M, Souidi M, Dessein AF, Wisztorski M, Vincent A, Gimeno JP, Monté D, Van Seuningen I, Gespach C, Huet G. Cross-talk between YAP and RAR-RXR Drives Expression of Stemness Genes to Promote 5-FU Resistance and Self-Renewal in Colorectal Cancer Cells.Mol Cancer Res. 2021 Apr;19(4):612-622. doi: 10.1158/1541-7786.MCR-20-0462. Epub 2021 Jan 20. PMID: 33472949.
Auwercx J, Rybarczyk P, Kischel P, Dhennin-Duthille I, Chatelain D, Sevestre H, Van Seuningen I, Ouadid-Ahidouch H, Jonckheere N, Gautier M. Mg<sup>2+</sup> Transporters in Digestive Cancers. Nutrients. 2021 Jan 13;13(1):210. doi: 10.3390/nu13010210. PMID: 33450887; PMCID: PMC7828344.
Neve B, Jonckheere N, Vincent A, Van Seuningen I. Long non-coding RNAs: the tentacles of chromatin remodeler complexes. Cell Mol Life Sci. 2021eb;78(4):1139-1161. doi: 10.1007/s00018-020-03646-0. Epub 2020 Oct 1. PMID: 33001247; PMCID: PMC11072783.